Application | Comment | Organism |
---|---|---|
medicine | gene therapy approaches involving Ndi1p may offer substantial clinical benefits in cases of complex I deficiency | Caenorhabditis elegans |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Caenorhabditis elegans | 5739 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
53000 | - |
SDS-PAGE | Caenorhabditis elegans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + H+ + ubiquinone | Caenorhabditis elegans | - |
NAD+ + ubiquinol | - |
? | |
NADH + H+ + ubiquinone | Caenorhabditis elegans N2 | - |
NAD+ + ubiquinol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | - |
- |
- |
Caenorhabditis elegans N2 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + H+ + ubiquinone | - |
Caenorhabditis elegans | NAD+ + ubiquinol | - |
? | |
NADH + H+ + ubiquinone | - |
Caenorhabditis elegans N2 | NAD+ + ubiquinol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alternative NADH:ubiquinone oxidoreductase | - |
Caenorhabditis elegans |
Ndi1p | - |
Caenorhabditis elegans |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | noncovalently bound | Caenorhabditis elegans | |
additional information | Ndi1p lacks iron sulfur clusters | Caenorhabditis elegans | |
NADH | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | Ndi1p functionally interacts with the nematode respiratory chain and contributes to the formation of the mitochondrial membrane potential in vivo. Ndi1p expression results in significantly improved reproductive success, better survival under conditions of oxidative stress, fewer signs of premature aging, increased respiration rates and a complete restoration of the in vivo mitochondrial membrane potential in Caenorhabditis elegans nuo-1 mutants. However, Ndi1p is not able to fully replace complex I and cannot support larval development when complex I is missing | Caenorhabditis elegans |